Charge density and particle size effects on oligonucleotide and plasmid DNA binding to nanosized hydrotalcite

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چکیده

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Charge density and particle size effects on oligonucleotide and plasmid DNA binding to nanosized hydrotalcite.

Hydrotalcite (HT) and other layered double metal hydroxides are of great interest as gene delivery and timed release drug delivery systems and as enteric vehicles for biologically active molecules that are sensitive to gastric fluids. HT is a naturally occurring double metal hydroxide that can be synthesized as a nanomaterial consisting of a brucite structure with isomorphous substitution of al...

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ژورنال

عنوان ژورنال: Biointerphases

سال: 2013

ISSN: 1934-8630,1559-4106

DOI: 10.1186/1559-4106-8-8